Leukemia Clinical Trials

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Measures to Lower the Stress Response in Pediatric Cardiac Surgery

NCT00848393

Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively. Through clinical observation, anesthesiologists have determined that varying the combinations of anesthesia drugs used during surgery and just after reduces the stress response, and by extension, morbidity and mortality. However, only a few studies have explored this phenomenon scientifically.

Tetralogy of Fallot (TOF)Ventricular Septal Defects (VSD)Atrioventricular Septal Defects (AVSD)

Nationwide Children's Hospital52 participantsStarted Nov 2008

Columbus, Ohio, United States

COMPLETEDPhase 2

Avastin +/- Erlotinib Consolidation Chemotherapy After Carboplatin, Paclitaxel, and Avastin (CTA) Induction Therapy for Advanced Ovarian, Fallopian Tube, Primary Peritoneal Cancer & Papillary Serous or Clear Cell Mullerian Tumors

NCT00520013

The purpose of this research study is to evaluate how patients with newly diagnosed advanced ovarian, fallopian tube, primary peritoneal cancer and papillary serous or clear cell mullerian tumors respond to consolidation therapy with Avastin and erlotinib or Avastin alone over 1 year. These drugs have been used in the treatment of other types of cancers and information from those studies suggests that these agents may help to treat the cancers studied here.

Ovarian CancerFallopian Tube CancerPrimary Peritoneal Cancer+2 more

Dana-Farber Cancer Institute60 participantsStarted Aug 2007

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States

Measures to Lower the Stress Response in Pediatric Cardiac Surgery

Avastin +/- Erlotinib Consolidation Chemotherapy After Carboplatin, Paclitaxel, and Avastin (CTA) Induction Therapy for Advanced Ovarian, Fallopian Tube, Primary Peritoneal Cancer & Papillary Serous or Clear Cell Mullerian Tumors

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