Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems. This study will help us determine if and how often these problems occur.

At your first visit you will be asked to do the following. * Sign this informed consent document. * Questionnaire: You will be asked to complete a questionnaire about your family history of neurological diseases and current and past physical thinking activities. * Interview: The interview will be performed by the study coordinator who is a member of the research team. It will take about 20-30 minutes to complete. You will be asked to answer questions about your general health, surgeries, medications, and your memory and thinking skills. * Memory Interview: You will have an evaluation of your memory and thinking skills. You will answer questions and perform tasks that evaluate various thinking abilities such as concentration, memory, reasoning, and learning. * Blood draw: Have a sample of blood drawn (4.2-5 tablespoons) for clinical and research tests. * Magnetic Resonance Imaging (MRI) of your brain (optional): If you agree to participate, you will be asked to have MR imaging of your brain. * Echocardiogram: You will be asked to have an echocardiogram of your heart. * Follow-up visit in 2-3 years: You will be asked to return to Mayo for your second study visit in 2-3 years. At this visit, you will be asked to complete the same memory and thinking tests described for the first visit. You will also be asked to repeat the echocardiogram.