Leukemia Clinical Trials

Showing 3301-3320 of 10,987 trials

Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas

NCT04305444

Targeted drug therapies have greatly improved outcomes for patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. However, single drug therapies have limitations, therefore, the current study is evaluating a novel oral combination of targeted drugs as a way of overcoming these limitations. This study will determine the efficacy of the triple combination therapy, DTRM-555, in patients with R/R CLL or R/R non-Hodgkin's lymphoma.

Relapsed Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic LeukemiaDiffuse Large B Cell Lymphoma+2 more

Zhejiang DTRM Biopharma55 participantsStarted Apr 2020

Phoenix, Arizona, United States • New Haven, Connecticut, United States • Jacksonville, Florida, United States +5 more locations

Not Yet RecruitingNA

NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL

NCT06763302

The goal of this clinical trial is to determine whether pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients with negative deep minimal residue disease (MRD) can benefit from blinatumomab treatment. The main questions it aims to answer are: 1. Whether the application of blinatumomab can improve the long-term survival of next generation sequence (NGS) MRD-positive B-ALL children after consolidation therapy? 2. Whether the application of blinatumomab can benefit the NGS MRD-negative B-ALL children after consolidation therapy?

B Cell Precursor Acute Lymphoblastic LeukemiaPediatricMinimal Residual Disease+1 more

The Children's Hospital of Zhejiang University School of Medicine1,220 participantsStarted Jan 2025

Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas

NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL

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