Short Repeated Nickel Exposures

Exclusion Criteria

• •Active eczema in test areas
• •Generalized eczema
• •Scar tissue in test areas.
• •Pregnancy or breast feeding
• •Treatment with topical corticosteroids or other immune-suppressants on/near test areas within four weeks prior to study start
• •Systemic immunomodulatory\* treatment within 4 weeks prior to study start
• •UV exposure of test areas within three weeks prior to study start
• •Participation in other clinical studies within four weeks prior to study start
• •Unable to cooperate or communicate with the investigators \*Systemic immunomodulatory treatment is drugs taken orally or by injection that modify the response of the immune system by increasing (immunostimulators) or decreasing (immunosuppressives) the production of serum antibodies
• •For Healthy volunteers:
• •History of contact allergy
• •Generalized eczema
• •Scar tissue in test areas.
• •Pregnancy or breast feeding
• •Treatment with topical corticosteroids or other immune-suppressants on/near test areas within four weeks prior to study start
• •Systemic immunomodulatory treatment within four weeks prior to study start
• •UV exposure of test areas within three weeks prior to study start
• •Participation in other clinical studies within four weeks prior to study start
• •Unable to cooperate or communicate with the investigators