Leukemia Clinical Trials

Showing 3021-3040 of 5,235 trials

Unilateral GPi vs Unilateral STN DBS in the Same Patient With PD

NCT04255719

The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two main targets in the deep brain stimulation (DBS) treatment for Parkinson's disease (PD). Large randomized controlled trials, in which patients of comparable clinical and demographics were randomized to either GPi DBS or STN DBS, have demonstrated equal effects of both targets in motor symptom improvement, the superiority of STN DBS in the medication reduction and the potential advantage of GPi DBS for cognitive, psychiatric and axial aspects. Unfortunately, in such a highly heterogeneous disease of PD, many of these randomized controlled trials didn't include sufficient subjects and thereby yielded inconsistent results. Moreover, most studies are investigating the difference between GPi and STN in different patients. In order to address the problem, an intra-patient comparison will be made by investigating the acute turning-on effects of unilateral STN stimulation versus unilateral GPi stimulation on axial symptoms, cognition and also cardinal symptoms within each individual patient who received the treatment of combined unilateral STN and contralateral GPi DBS. Axial symptoms including gait, balance and posture, motor symptoms and cognition are comprehensively assessed under two treatment conditions.

Parkinson DiseaseDeep Brain StimulationGlobus Pallidus Interna+1 more

Ruijin Hospital9 participantsStarted Mar 2020

Shanghai, Shanghai Municipality, China

COMPLETED

Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects

NCT01110863

By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.

Chronic Lymphocytic Leukemia

Northwell Health90 participantsStarted Dec 2005

Manhasset, New York, United States

Unilateral GPi vs Unilateral STN DBS in the Same Patient With PD

Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects

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