Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)

Inclusion Criteria

• •1. Inclusion within 3 months after diagnosis
• •2. Availability of a cryopreserved tumour sample (primary and/or metastatic and/or lymph nodes) or peripheral blood or bone marrow samples (if invasion more than 30% of lymphoblasts) for leukaemias, obtained at the time of diagnosis during a routine procedure
• •3. Availability of a formalin-fixed paraffin-embedded (FFPE) tumour sample (primary and/or metastasis and/or lymph nodes), obtained at the time of diagnosis during a routine procedure (except for leukaemia patients)
• •4. Age: ≤ 25 years at diagnosis
• •5. Written patient informed consent, or parents or legal representative written informed consent and assent of the child and the adolescent
• •6. Compulsory affiliation to a social security scheme
• •To avoid multiple sampling for children, adolescents and young adults with cancer, patients already included or to be included in a study with similar analyses and/or objectives might also be included in MICCHADO study and in this case, samples or data might be exchanged on a collaborative basis.
• •Cohort 1:
• •* High risk neuroblastoma:
• •\- Any type of neuroblastoma with MYCN amplification, except INSS stage 1
• +35 more criteria