Kidney Disease Clinical Trials

Showing 2641-2660 of 3,902 trials

Pentoxifylline and Systemic Inflammation in Hemodialysis Patients

NCT01269827

The aim of this study was to compare the effect of PTX vs placebo on serum concentrations of TNF-α, IL-6, and CRP in patients on hemodialysis.

InflammationEnd-stage Renal DiseaseHemodialysis

Coordinación de Investigación en Salud, Mexico36 participantsStarted Jan 2006

Guadalajara, Jalisco, Mexico

COMPLETEDPhase 4

Use of Telmisartan and Captopril in Inflammation of Hemodialysis Patients

NCT01271478

The aim of this study was to compare the dual use of telmisartan and captopril vs the individual use of such drugs and placebo on the systemic inflammation of patients on hemodialysis (HD).

InflammationEnd-stage Renal Disease

Coordinación de Investigación en Salud, Mexico60 participantsStarted Aug 2009

Guadalajara, Jalisco, Mexico

COMPLETEDPhase 4

Renoprotective Effects of Telbivudine in Chronic Hepatitis B

NCT03778567

Renal impairment is common in patients with chronic hepatitis B infection. For those taking nucleotide analogues, renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. In this prospective study, consecutive CHB patients on combined lamivudine (LAM)+ADV/TDF are switched to LdT+ADV/TDF at recruitment and are followed up for 24 months. Estimated glomerular filtration rate (eGFR) is calculated with the Modification of Diet in Renal Disease (MDRD) equation. The effects of LdT on cell viability and expression of kidney injury or apoptotic biomarkers are investigated in cultured renal tubular epithelial cell line HK-2.

Hepatitis B, ChronicChronic Kidney Diseases

The University of Hong Kong31 participantsStarted Aug 2013

Hong Kong, Hong Kong

Pentoxifylline and Systemic Inflammation in Hemodialysis Patients

Use of Telmisartan and Captopril in Inflammation of Hemodialysis Patients

Renoprotective Effects of Telbivudine in Chronic Hepatitis B

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