Epilepsy Clinical Trials

Showing 341-360 of 429 trials

Doxycycline for the Treatment of Nodding Syndrome

NCT02850913

Nodding syndrome (NS) is a devastating neurologic disorder affecting thousands of children in Africa. A number of toxic, nutritional, infectious, para-infectious and environmental causes have been studied but the only consistent association has been with infection by the parasite Onchocerca volvulus. There is no specific treatment for NS and also for the adult onchocerca. However, antibiotic depletion of the Onchocerca volvulus co-symbiotic bacteria Wolbachia with tetracyclines such as doxycycline results in sterilisation and premature death of the adult worm and marked reductions in dermal microfilaria density. Potentially, such therapy that kills adult onchocerca volvulus may improve the outcome of NS if the association were true.

Seizures

Makerere University230 participantsStarted Sep 2016

Kampala, Uganda

COMPLETEDPHASE3

Lamotrigine Extended-Release In Elderly Patients With Epilepsy

NCT00516139

This study is being conducted to determine the safety and tolerability of lamotrigine (LTG) in elderly patients with epilepsy. This study will be carried out using an extended-release formulation of lamotrigine (LTG-XR) that will allow once-a-day dosing.

Epilepsy

GlaxoSmithKline122 participantsStarted Aug 2007

Birmingham, Alabama, United States • Gilbert, Arizona, United States • Litchfield Park, Arizona, United States +60 more locations

Doxycycline for the Treatment of Nodding Syndrome

Lamotrigine Extended-Release In Elderly Patients With Epilepsy

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