Chronic Pain Clinical Trials

Showing 121-140 of 491 trials

Influence of Preoperative Fear on Pain and Postoperative Outcomes

NCT06785389

Fear of anesthesia plays a crucial role in the perioperative setting and can negatively affect recovery. The main objective is to assess the relationship between fear of anesthesia, surgeries, and hospitals and poorer postoperative pain control in patients undergoing scheduled surgery, as well as to relate preoperative anxiety to postoperative analgesic assessment in this population. This is a prospective observational study including 138 patients scheduled for surgery.

FearPain ManagementAnxiety+1 more

Dr. Negrin University Hospital138 participantsStarted Jan 2025

Las Palmas de Gran Canaria, Las Palmas, Spain

COMPLETEDPHASE2/PHASE3

Does Subacromial Injection With Glutamate Receptor Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy?

NCT02967640

The hypothesis of the present study is that in patients with rotator cuff tendinopathy a specific pharmacological blocking of peripheral glutamate-receptor N-methyl-d-aspartate receptor type1 (NMDAR) glutamate receptors will result in pain alleviation. Activated NMDAR1 has been demonstrated to be crucial for pain regulation in various pain disorders, and in biopsies from patients with tendinopathy, NMDAR1 was found to be activated. To test this hypothesis a specific NMDA receptor antagonist, ketalar (ketamine), will be injected guided by ultrasound into the subacromial space in patients with rotator cuff tendinopathy, and subsequently the pain response will be assessed.

Rotator Cuff TendinitisChronic Pain

Helse Møre og Romsdal HF14 participantsStarted May 2018

Kristiansund, Norway

Influence of Preoperative Fear on Pain and Postoperative Outcomes

Does Subacromial Injection With Glutamate Receptor Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy?

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