Breast Cancer Clinical Trials

Showing 1501-1520 of 5,597 trials

Extracellular Vesicles in Breast Cancer Patientsin Undergone Neoadjuvant Chemotherapy

NCT05831397

Extracellular vesicles (EVs) are lipid bilayer-delimited particles, naturally released from the cells and mediators of intercellular cross-talk. In breast cancer (BC), EVs seem to be involved in the tumor microenvironment's shaping, in cancer cells invasion and in the set-up of metastasis. Clinical studies have provided initial evidence that EVs may have a prognostic and predictive value in breast cancer. Considering their presence in body fluids and their minimally invasive assessment through blood sampling, EVs could be liquid biopsy-derived biomarkers. Their quantification could be a complex challenge, requiring complicated and time-consuming pre-analytical procedures of EVs isolation. A new method for the detection of tumor-derived-EVs associated proteins is based on the use of Single Molecule Array (SiMoA), a digital ELISA technology able to detect and quantify extremely low concentrations of target proteins or particles. The aim of this study is to evaluate how this new technology can allow the quantification EVs plasma levels in patients affected by BC, providing useful diagnostic and prognostic information about the efficacy of the neoadjuvant treatment.

Breast Cancer

Istituti Clinici Scientifici Maugeri SpA35 participantsStarted May 2021

Pavia, Lombardy, Italy

Active Not Recruiting

Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy

NCT04769960

The purpose of this study is to find out whether it is safe to perform MRI scans in people who have breast tissue expanders in place.

Breast CancerBreast NeoplasmsBreast Adenocarcinoma

Memorial Sloan Kettering Cancer Center68 participantsStarted Feb 2021

Montvale, New Jersey, United States • Commack, New York, United States • New York, New York, United States

Extracellular Vesicles in Breast Cancer Patientsin Undergone Neoadjuvant Chemotherapy

Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy

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