Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Arizona
With
National Cancer Institute (NCI)
PRIMARY OBJECTIVES:
I. To assess the changes in the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the lower extremity nerves by diffusion tensor imaging (DTI) before initiation and after completion of taxane chemotherapy in patients with breast cancer.
SECONDARY OBJECTIVES:
I. Establish normal and abnormal FA and ADC values of the lower extremity nerves.
II. Evaluate relationship of DTI findings of chemotherapy induced peripheral neuropathy (CIPN) with self-reported Patient Neurotoxicity Questionnaire (PNQ) and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-neurotoxicity questionnaire (FACT-GOT-NTX) questionnaires.
III. Assess inter-reader variability in measuring FA and ADC values.
OUTLINE:
Patients undergo non-enhanced magnetic resonance imaging (MRI) of both lower extremities using magnetic resonance neurography (MRN) and DTI prior to initiation and after completion of standard of care chemotherapy.
Age
21–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Be capable of understanding the investigational nature of the study and all pertinent aspects of the study
Be capable of signing and providing written consent in accordance with institutional and federal guidelines
Have a histologically-confirmed diagnosis of breast cancer
Need to be treated with taxane containing chemotherapy as determined by their treating physician
Be able to undergo magnetic resonance (MR) imaging
Be willing and able to comply with scheduled visits, treatment plan, and MR imaging
You may not be if
Have non-MRI compatible metallic objects on/in body
Have metallic hardware in the lower extremity which is MR compatible however would create too much artifact for MR examination
Are unable to lay still in the MR scanner for length of examination
Have severe claustrophobia
Have pre-existing peripheral neuropathy from other medical conditions or due to cancer
Have diagnosis of diabetes
Pregnant patients
Prior exposure to neurotoxic chemotherapy
Clareo Health | Diffusion Tensor Imaging in Predicting Development of Chemotherapy Induced Peripheral Neuropathy in Patients With Breast Cancer (CIPN)
