Breast Cancer Clinical Trials

Showing 121-140 of 2,749 trials

Patient-Derived Breast Cancer Organoids for Therapeutic Extracellular Vesicle Isolation (PDO-Mercurial01)

NCT07421479

The aim of this study is to establish organoid cultures, which are three-dimensional in vitro tumor models capable of supporting the long-term ex vivo growth of tumor cells derived from patients with breast carcinoma. These organoids will be used for the isolation of extracellular vesicles (EVs), which are naturally released by cells and have the ability to selectively recognize tumor tissue. Due to these properties, EVs represent promising vectors for the targeted delivery of diagnostic agents, with potential applications in fluorescence-guided surgery.

Invasive Breast Cancer

Istituti Clinici Scientifici Maugeri SpA50 participantsStarted Jan 2025

Pavia, Italy

ACTIVE_NOT_RECRUITINGPHASE1/PHASE2

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

NCT04644068

This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.

Ovarian CancerBreast CancerPancreatic Cancer+10 more

AstraZeneca702 participantsStarted Nov 2020

Boston, Massachusetts, United States • Boston, Massachusetts, United States • New York, New York, United States +65 more locations

Patient-Derived Breast Cancer Organoids for Therapeutic Extracellular Vesicle Isolation (PDO-Mercurial01)

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

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