Breast Cancer Clinical Trials in Philadelphia

Showing 201-220 of 391 trials

A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.

NCT03840200

This is a study in participants with advanced breast, ovarian, or prostate cancer to investigate the dose, safety, pharmacokinetics, and preliminary efficacy of ipatasertib in combination with rucaparib. The study consists of two parts: a Dose-Escalation Phase (Part 1) in participants with previously treated advanced breast cancer, ovarian cancer, or prostate cancer and a Dose-Expansion Phase (Part 2) in participants with advanced prostate cancer who have had at least one line of prior therapy with second-generation androgen-receptor (AR)-targeted agents (e.g., abiraterone, enzalutamide, apalutamide).

Breast CancerProstate CancerOvarian Cancer

Hoffmann-La Roche51 participantsStarted Jun 2019

San Marcos, California, United States • East Brunswick, New Jersey, United States • Philadelphia, Pennsylvania, United States +14 more locations

COMPLETEDPHASE1< 1 mile

Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion

NCT01997190

This is a phase I study of intrapleural AdV-tk therapy in patients with malignant pleural effusion (MPE). The primary objective is to test the safety of intrapleural AdV-tk therapy. Secondary objectives are to evaluate clinical efficacy and biologic activity

Malignant Pleural EffusionLung CancerMesothelioma+2 more

Candel Therapeutics, Inc.19 participantsStarted Oct 2013

Philadelphia, Pennsylvania, United States

A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.

Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion

Breast Cancer Trials in Other Cities

A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer

Autologous T Cells Expressing MET scFv CAR (RNA CART-cMET)

Identification of Genes Associated With Cancer in Patients and Siblings Who Have Cancer

Drug Resistance Inhibition in Treating Women With Recurrent or Metastatic Breast Cancer

A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors

TAC Versus TC for Adjuvant Breast Cancer

Combination Chemotherapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Has Spread to the Lymph Nodes

Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC

A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer

Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer

Aerobic Training in Metastatic Breast Cancer

Investigation of Novel Surgical Imaging for Tumor Excision

Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer

Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene

Breast Cancer Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer

A Study Assessing the Safety and Effectiveness of IC2000 and SPY Fluorescence Imaging Systems (SPY-PHI) in the Visualization of Lymphatic Vessels and Identification of Lymph Nodes During Sentinel Lymph Node Biopsy in Subjects With Breast Cancer

Estimation of the Prevalence of HER2 Low and Describe the SoC, Treatment Patterns, and Outcome in Real-world Practice Among Unresectable and/or Metastatic Breast Cancer Patients With HER2 Low Status

Fulvestrant + Neratinib In Breast Cancer

Other Conditions in Philadelphia