Breast Cancer Clinical Trials in Boston

Showing 221-240 of 598 trials

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

NCT02326974

This research study is studying a combination of drugs as a possible treatment for breast cancer that has tested positive for a protein called HER2. The names of the study interventions involved in this study are: * Trastuzumab emtansine (also called T-DM1) * Pertuzumab

HER-2 Positive Breast CancerBreast CancerStage II Breast Cancer+1 more

Dana-Farber Cancer Institute164 participantsStarted Jan 2015

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Nashville, Tennessee, United States +1 more locations

COMPLETEDPhase 1< 1 mile

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

NCT04246671

A Phase 1 open label trial of intravenous administration of TAEK-VAC-HerBy vaccine in patients with advanced brachyury and/or HER2- expressing cancer. The study will be completed in 2 stages. In Stage 1 patients will be enrolled and treated according to a 3+3 dose escalation scheme. Up to 4 dose levels will be explored to determine the recommended dose of TAEK-VAC-HerBy for Stage 2 of the trial. Stage 2 will enroll either chordoma patients for treatment with TAEK-VAC-HerBy alone, or HER2- positive breast cancer patients for combination treatment of TAEK-VAC-HerBy vaccine and therapeutic HER2 antibodies (trastuzumab). Patients in both stages will receive TAEK-VAC-HerBy intravenously, every three weeks, three administrations in total.

ChordomaHER2-positive Breast Cancer

Bavarian Nordic37 participantsStarted Aug 2020

Scottsdale, Arizona, United States • Santa Monica, California, United States • Jacksonville, Florida, United States +6 more locations

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

Breast Cancer Trials in Other Cities

Multicenter Hologic Tomosynthesis Study

Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer

Searching for Masses and Calcifications at the Same Time in Breast Cancer Screening

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast Cancer Which Progressed on or After Aromatase Inhibitor Treatment.

The PROMISE Study: Duavee in Women With DCIS

The OPBC-07/microNAC Study

Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation

Feasibility Study of Intraoperative Detection of Residual Cancer in Breast Cancer Patients

Contrast Enhanced Spectral Mammography vs. MRI for Breast Cancer Screening

Alcohol and Breast Cancer (ABC) Trial

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

PhII ICb With/Without Erbitux in MBC Pts

Trilaciclib in Patients Receiving Sacituzumab Govitecan-hziy for Triple Negative Breast Cancer

Trastuzumab Deruxtecan With Nivolumab in Advanced Breast and Urothelial Cancer

Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors

Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

A Study to Investigate the Biological Effects of AZD9833 in Women With ER-positive, HER2 Negative Primary Breast Cancer

Other Conditions in Boston