* Established atherosclerotic cardiovascular disease (ASCVD)
* Obesity (body mass index (BMI) ≥30 kg/m2)
* Type 2 diabetes
* Hypertension
* Chronic kidney disease Grade 3 or 4
You may not be if
Acute cardiovascular event within 60 days prior to screening
Acute decompensated heart failure hospitalization within 60 days prior to screening
Planned coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or major surgery at the time of randomization
New York Heart Association Class III or IV heart failure
Uncontrolled hypertension at screening (systolic blood pressure (BP) ≥160 mmHg or diastolic BP ≥100 mmHg)
Type 1 diabetes
Type 2 diabetes with Hemoglobin A1c ≥9.0% (86 mmol/mol) at screening
Nephrotic syndrome, estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73 m², or history of kidney transplant
Dialysis or acute kidney injury within 60 days prior to screening
