IMMUNO-LUNG : Identification of Biomarkers and Therapeutic Targets for Pulmonary Immunotherapy

The primary objective of this clinical study is to understand how certain blood markers can predict the effectiveness of immunotherapy treatments for patients with advanced-stage lung cancer. This is a multicenter study with a total duration of 7 years. In addition, the study will address several secondary objectives: Compare biological markers present in the blood with those found in lung cancer tumors. Investigate differences between tumor markers at early versus advanced stages of the disease. Identify new markers that may predict the effectiveness of immunotherapy treatments. Explore a specific mechanism (called HVEM/BTLA) involved in lung cancer, whether at an early or advanced stage. To achieve the study objectives, 200 patients are expected to be enrolled, and the study will be conducted across two institutions. In this study, the following biological samples will be collected: blood and tissue samples at the time of inclusion, and again at disease progression if it occurs during follow-up.