The patient has a diagnosis of depression, according to DSM-5, and in treatment with Vortioxetine (for no more than a week).
Patients with depression and anxiety symptoms will also be included in the study
The patient had a score of the HAM-D \>18 (moderate to severe)
The patient has a diagnosis of episodic migraine with and without aura according to ICHD-3 criteria confirmed at the Screening Visit with a history of migraine onset of at least one year before the Screening Visit
No concomitant other treatment for depression
The patient has had an onset of migraine at \<50 years of age
All participating patients will provide written informed consent
You may not be if
Stable treatment for migraine for at least two months without prevision to change it in the next two12 weeks
The patient has confounding and clinically significant pain syndromes (for example, chronic low back pain and fibromyalgia)
The patient has a history or diagnosis of chronic tension-type headache, hypnic headache, cluster headache, hemicrania continua, new daily persistent headache, or unusual migraine subtypes such as hemiplegic migraine (sporadic and familial), or migraine with brainstem aura
Patients with a lifetime history of psychosis, bipolar mania
Patients with cognitive impairment are excluded (MoCA \<26)
Clareo Health | Vortioxetine in Depression and Concomitant Migraine
