Study of IBI3016 in People With Mild or Moderate Hypertension Patients

Exclusion Criteria

• •1. Known history of secondary hypertension.
• •2. Orthostatic hypotension.
• •3. Laboratory parameter assessments outside of range at screening：
• •* Alanine Aminotransferase (ALT) or Aspartate Aminotransferase (AST) \> 2× Upper Limit of Normal (ULN)
• •* Total Bilirubin \> 1.5× ULN
• •* International Normalized Ratio (INR) \> 2.0
• •* Serum Potassium \> 5 mmol/L
• •* Estimated Glomerular Filtration Rate (eGFR) ≤ 45 mL/min/1.73m²
• •* QTcF \> 480 ms
• •4. Medical condition, other than hypertension, requiring treatment with RAAS inhibitor.
• •5. Current or history of intolerance to ACEi and/or ARBs.
• •6. Acute myocardial infarction (AMI), unstable angina, percutaneous coronary intervention (PCI) , coronary artery bypass graft (CABG), ischemic or hemorrhagic stroke, transient ischemic attack, or clinically significant cardiac arrhythmias within 6 months prior to screening, or a previous diagnosis of decompensated heart failure or New York Heart Association (NYHA) grade III or IV heart failure.