Cold and Compression Post TKA

Cold and Compression After Total Knee Arthroplasty for Pain Attenuation: A Randomized, Controlled Trial

NCT07023185•Ochsner Health System

Summary

The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14 days, then weekly after surgery for 3 months, and at 6 months post-surgery.

Eligibility

Age

50 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Aged 50 yr or older
•2. Patient of Dr. Howard Hirsch or Dr. Vinod Dasa scheduled for total knee arthroplasty (knee replacement) at Ochsner Kenner
•3. Will receive outpatient physical therapy at OTW Driftwood for the entire post-op rehabilitation period
•4. English speaking
•5. Diagnosis of primary osteoarthritis

Exclusion Criteria

•1. Chronic opioid use
•2. Opioid use within the last 3 months
•3. PCS score ≥ 30
•4. Diagnosis of inflammatory disease process (i.e., gout, rheumatoid arthritis, systematic lupus erythematosus...)
•5. Discharge to skilled nursing
•6. Cold intolerance related to diseases, like Raynaud's
•7. Significant vascular impairment in the affected region
•8. Current clinical signs of inflammatory phlebitis, venous ulcers, or cellulitis
•9. Significant risk factors or current clinical signs of embolism (e.g., pulmonary embolus, pulmonary edema, cerebral infarction, atrial fibrillation, endocarditis, myocardial infarction, or atheromatous embolic plaque)
•10. A condition in which increased venous or lymphatic return is not desired in the affected extremity (e.g., lymphedema after breast cancer or other local carcinoma and/or carcinoma metastasis in the affected extremity).
+38 more criteria

Locations (1)

Ochsner Medical Center - Kenner

New Orleans, Louisiana, United States

Key Dates

Start Date

December 15, 2025

Primary Completion Date

June 1, 2027

Completion Date

June 1, 2028

Last Updated

December 30, 2025

Enrollment

ESTIMATED participants

Conditions

Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery

Interventions

Cold and Compression

DEVICE

SOC (Standard of care)

OTHER

Contacts

Vinod Dasa, MD

CONTACT

(504) 412-1705 vdasa@lsuhsc.edu

Ken Bode

CONTACT

504-842-1936 ken.bode@ochsner.org