A Phase 1 Study of JADE201 in Participants With Rheumatoid Arthritis

Exclusion Criteria

• •1. With the exception of RA, known history of clinically significant disease
• •2. Diagnosis or symptoms suggestive of any systemic autoimmune or inflammatory condition other than RA
• •3. positive serology for Hep A, Hep B, or Hep C virus
• •4. Positive, indeterminate, or invalid test of TB
• •5. Current tobacco users who smoke \>5 cigarettes per day or equivalent
• •6. Nursing, lactating or pregnant, or who have plans to become pregnant during the study
• •7. Treatment with an investigational drug within 30 days or 5 half lives prior to study drug administration