Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Ability and willingness to provide informed consent
Age at least 18 years old
Diagnosis of UC based on clinical and endoscopic criteria
UC duration of at least 3 months
Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score ≤4 within 90 days of randomization
On a stable dose or no existing UC therapies (apart from steroids) for defined periods (as outlined below).
1. ≥4 weeks if no medication, 5-ASA
2. ≥8 wk for immunomodulatory therapy
3. ≥12 wk for biologics
Ability to comply with study requirements in the opinion of the primary investigator

Moderate or severe UC as defined by UCEIS ≥5
History of stomach surgery or bowel resection
Antibiotic use within 3 months
Anticipated antibiotic exposure during the study period (e.g. perioperative antibiotics)
Pregnancy or breastfeeding
History of anaphylactic food allergies
Intolerance of high dietary fiber content
Ongoing alcohol or drug abuse
Habitual vegan diet pattern
Insufficient freezer space to accommodate meal delivery

Microbiome-targeted Diet Therapy in Ulcerative Colitis