The Sponsor is studying an investigational medication called tonlamarsen to determine if it can help people recently treated for acute severe hypertension (hypertensive emergency and urgency).
The purpose of this study is to evaluate how well tonlamarsen works compared to a placebo and to see how safe it is for people following a recent episode of acute severe hypertension. Tonlamarsen is designed to block the body's liver from making a protein called angiotensinogen (AGT), which plays a key role in controlling blood pressure.
The main goals of the study are:
* To assess the effect of tonlamarsen on the amount of AGT in blood over time
* To assess the effect of tonlamarsen on blood pressure
* To evaluate the safety and tolerability of tonlamarsen
Participants will:
* Receive monthly doses of tonlamarsen for approximately 3 months
* Visit the clinic about 7 times, including initial evaluation, checkups, tests, and follow-up
