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A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation | Clinical Trials | Clareo Health

NOT_YET_RECRUITING

A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation

NCT07484126•Southeast University, China

View on ClinicalTrials.gov

Summary

This study used a retrospective cohort study based on Multi-time longitudinal monitoring data were used to analyze the correlation mechanism between the dynamic evolution characteristics of nutrition-related biochemical indicators and individualized nutritional intervention in patients with mechanical ventilation. The inflammation-nutrition interaction model was constructed to correct the interference effect of inflammatory microenvironment on nutritional status assessment, so as to provide a basis for further achieving precision nutritional support.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•age ≥18 years old;
•ICU admission ≥72 hours with invasive mechanical ventilation ≥24 hours;
•start nutrition therapy within 72 hours after ICU admission and receive enteral or parenteral nutrition support for ≥3 days;
•Relatively complete nutritional intervention records and nutrition-related biomarkers test results on the 1st, 3rd, and 7th (±1) days of ICU admission;

Exclusion Criteria

•women of childbearing age who have a positive pregnancy test, are pregnant or lactating;
•chronic diseases with serious organ function damage or serious complications;
•1. Kidney: chronic kidney disease stage 4 or 5;
•2. Liver: previous history of liver failure, hepatic encephalopathy, or hepatic coma, gastrointestinal bleeding due to portal hypertension or Child-Pugh score ≥10 in recent years;
•advanced malignant tumor, or chemotherapy or immunotherapy received within one month before admission;
•severe immunodeficiency or current use of potent immunosuppressive agents, agranulocytosis (N\<0.5×10\^9/L), active hematologic malignancies or HIV stage III infection; Patients who were treated with immune-inducing drugs, such as antithymocyte globulin (ATG), antilymphocyte globulin (ALG), interleukin-2 receptor a chain antibody (IL-2RA), interleukin-6 receptor A antibody (IL-6RA); glucocorticoid therapy was continued for nearly 2 weeks, with a daily dose exceeding the hydrocortisone equivalent of 200mg;
•critical illness, death in ICU within 1 week or palliative care only because death outcome was inevitable;
•combined with severe or more severe burns: more than 30% of total body surface area burned or more than 10% of third-degree burn area; Or the total area is less than 30%, but the whole body condition is severe, or there are shock, combined injury, and respiratory tract burn.

Key Dates

Start Date

April 1, 2026

Primary Completion Date

August 1, 2026

Completion Date

August 1, 2026

Last Updated

March 19, 2026

Enrollment

2,000

ESTIMATED participants

Conditions

Mechanical Ventilation

Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID)

NCT07467551

Mechanical VentilationPain Perception+1 more

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RECRUITINGNA

Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery

NCT07430111

ObesityBariatric Surgery+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 19, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation

Inclusion Criteria

Exclusion Criteria

Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID)

Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

Effect of Interferon Gamma as a Treatment for Post-aggressive Immunosuppression in Intensive Care Units, a Randomized Bayesian Double-blind Controlled Trial Versus Placebo

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score