A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers

Exclusion Criteria

• •1. Subjects with suspected glioma or other brain cancers who do not have a tissue diagnosis and no surgical biopsy or resection is anticipated.
• •2. Subjects in whom diagnostic cerebral angiogram is contra-indicated defined as:
• •* Severe contrast allergy
• •* Acute/chronic renal dysfunction with eGFR \< 45 ml/min and Cr ≤ 1.5 mg/dL
• •3. For participants undergoing surgery, refractory coagulopathy or thrombocytopenia which cannot be corrected defined as:
• •* Platelets ≤100,000/mcL
• •* International Normalized Ratio ≤ 1.7
• •4. Subjects that have a known high risk in monitored anesthetic care or general anesthesia assessed by the treating physician.
• •5. Anatomic considerations: based on cross-sectional imaging such as CT angiogram of the head and neck, the anatomy for arterial and venous vascular access is deemed unsuitable for endovascular access such as high-grade carotid artery stenosis, absent or occluded internal jugular veins, sigmoid sinuses and/or transverse sinuses.
• •6. Participants with clinical cerebral edema evidenced from altered mental status
• •7. Pregnant women due to risk of radiation exposure to the fetus, as determined by pregnancy urinalysis or serum analysis test during screening.
• •8. Subjects with psychiatric illness/social situations that would limit compliance with study requirements at the physician's discretion.