The Guiding Value of Liquid Biopsy Based on Urinary Tumor DNA/RNA in the Second Transurethral Resection of High-risk Non-muscle Invasive Bladder Cancer

Inclusion Criteria

• •Participants must meet all of the following criteria to be eligible for the study:
• •1. Male or female, aged 18 years or older.
• •2. Histologically confirmed non-muscle-invasive bladder tumor, with no evidence of muscle-invasive bladder cancer or metastatic disease.
• •3. Histologically confirmed urothelial carcinoma of the bladder or bladder tumor with urothelial carcinoma as the predominant component (\>50%).
• •4. At least one of the following conditions:
• •1. Incomplete initial transurethral resection of bladder tumor (TURBT) or suspected incomplete resection.
• •2. Absence of detrusor muscle in the initial TURBT pathological specimen (except for low-grade Ta stage tumors or carcinoma in situ \[CIS\]).
• •3. T1 stage tumor.
• •5. Willingness to provide a 50 mL urine sample between 2-6 weeks after the initial TURBT and prior to re-TURBT.
• •6. Willingness to provide tumor tissue samples for pathological examination.
• •7. Willingness to undergo genetic testing required for the trial.
• •8. Voluntarily agrees to participate in the study, has signed informed consent, demonstrates good compliance, and is willing to complete study follow-up.