Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver Cirrhosis

The primary aim of this study is to prospectively identify factors that predict decompensation, ACLF and death in patients with cirrhosis. Specific goals of the study: * To study the 1-, 3- and 5-year risk of decompensation, ACLF and death in patients with compensated and decompensated liver cirrhosis in Singapore * To identify clinically relevant point-in-time predictors and biomarkers for liver decompensation in general, and for specific liver-related events (including variceal bleeding, ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, portal vein thrombosis, portopulmonary hypertension, hepatopulmonary syndrome, cirrhotic cardiomyopathy, hepatorenal syndrome, refractory ascites, sarcopenia, and liver cancer) * To study the impact of underlying etiology of liver disease on the rate of decompensation, ACLF and death in liver cirrhosis * To provide external validation of predictive scores for decompensation (ALBI, CHESS-ALARM, LSPS, PREDICT, etc). * To serve as a core (hub) study for prospective ancillary studies regarding diagnosis, prognosis, and pathogenesis of AD and ACLF