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The Effect of Fluoxetine Treatment on Anger Processing in Healthy Young People
The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.
Age
18 - 24 years
Sex
ALL
Healthy Volunteers
Yes
Department of Psychiatry, University of Oxford
Oxford, Oxfordshire, United Kingdom
Start Date
October 1, 2025
Primary Completion Date
December 31, 2026
Completion Date
December 31, 2026
Last Updated
February 20, 2026
80
ESTIMATED participants
Fluoxetine
DRUG
Placebo
DRUG
Lead Sponsor
University of Oxford
Collaborators
NCT07360600
NCT06793397
Data Source & Attribution
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