The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

Association of the Exercise-Irisin-EEG Cascade With Intrinsic Brain Vulnerability and Its Impact on Postoperative Delirium in Elderly Patients: A Prospective Cohort Study

NCT07424170•Peking University People's Hospital

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Summary

The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.

Eligibility

Age

65 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Aged ≥ 65 years;
•Classified as ASA physical status I to III;
•Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;
•Expected surgical duration of at least 2 hours;
•Voluntarily provide written informed consent and agree to participate in this study.

Exclusion Criteria

•Significant change in exercise status within the past 7 days due to injury or other reasons;
•Contraindications to neuraxial anesthesia;
•Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \< 23;
•Preoperative diagnosis of delirium;
•History of traumatic brain injury or neurosurgery;
•Long-term opioid use or history of alcohol abuse;
•Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);
•Change in anesthesia method.

Key Dates

Start Date

March 15, 2026

Primary Completion Date

December 26, 2026

Completion Date

December 31, 2026

Last Updated

March 10, 2026

Enrollment

140

ESTIMATED participants

Conditions

Post Operative Delirium

Interventions

Preoperative physical activity level

BEHAVIORAL

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 10, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

Inclusion Criteria

Exclusion Criteria

A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Association of EEG Parameters with Postoperative Delirium in Patient's with Parkinson's Disease

The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery.