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A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery | Clinical Trials | Clareo Health

RECRUITINGNA

A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

A Multi-center, Randomized, Double-blinded, Placebo-controlled Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

NCT05242419•Second Affiliated Hospital of Wenzhou Medical University

View on ClinicalTrials.gov

Summary

To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery

Eligibility

Age

75 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•≥ 75 years old.
•Comply with the indication of non-cardiac surgery under general anesthesia.
•Anesthesia grade of American Society of Anesthesiologist (ASA) as III\~IV grade.
•The estimated operation time ≥ 2 hours.
•Voluntarily sign the informed consent form.

Exclusion Criteria

•Patients with impaired renal function (Cr is 1.5 times higher than the upper limit of the normal value of the central laboratory) or abnormal liver function (Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST) are 2 times higher than the upper limit of the normal value of the central laboratory).
•Patients who are positive for infectious diseases.
•Patients accompanied with central nervous system injury.
•Patients with previous history of delirium and epilepsy, long-term use of psychoactive drugs or preoperative assessment of delirium.
•Patients who involved diseases with drug taboos, bronchial asthma, mechanical intestinal obstruction and urinary tract obstruction, or serious systemic diseases, especially circulatory diseases: such as myocardial infarction, heart failure, angina pectoris, history of sinus bradycardia.
•Patients who are known to be allergic to narcotic drugs or Huperzine A Injection, or must use drugs that are not compatible with Huperzine An Injection.
•patients who participated in other clinical trials within 3 months before this study, for any reason, who could not tolerate the test or cooperate with the examination, or who has any aphasia, audio-visual dysfunction, etc.
•the investigators think that the patients is not suitable to participate in this study.

Locations (1)

The 2nd Second Affiliated Hospital of WMU Phase I Clinical Trial Unit /Center Of Bioequivalence Study

Wenzhou, Zhejiang, China

Key Dates

Start Date

June 10, 2022

Primary Completion Date

November 30, 2025

Completion Date

December 30, 2025

Last Updated

April 2, 2025

Enrollment

ESTIMATED participants

Conditions

InjectionNon-cardiac SurgeryDelirium in Old AgePost Operative Delirium

Interventions

Sodium Chloride Injection

DRUG

Huperzine A Injection

DRUG

Contacts

Ting Li, MD. PhD

CONTACT

13587876896 liting1021@aliyun.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 2, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

Inclusion Criteria

Exclusion Criteria

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