Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation

Exclusion Criteria

• •History of major neurological or psychiatric disorders, including substance use disorders that might confound brain imaging results (e.g., stroke, epilepsy, multiple sclerosis, schizophrenia, major depression requiring hospitalization).
• •Diagnosis of Type 2 Diabetes.
• •Use of medications affecting weight other than tirzepatide.
• •Pregnancy or breastfeeding.
• •MR contraindications:
• •Heart pacemaker, heart valve replacement, or aortic clips
• •Metal fragments in the eyes, skin, or elsewhere in the body
• •Brain clips or pieces of metal used in aneurysm surgery or intercranial bypass
• •Venous umbrella
• •Pieces of metal in the body resulting from work as a sheet-metal worker or welder
• •Clips placed in an internal organ
• •Prosthetic devices, such as middle ear, eye, joint, or penile implants
• •Joint replacement
• •Hearing aid that cannot be removed
• •Neurostimulator
• •Insulin pump
• •Shunts or stents
• •Metal mesh or coil implants
• •Metal plate, pin, screws, or wires, or any other metal implants