Ketoanalogue Supplementation for Muscle Protection in CKD 4 and 5 Patients With Moderately Low Protein Diet (KETO-PROT-ACTION)

Exclusion Criteria

• •Hospitalization in the past 3 months
• •Corticosteroids (\> 7.5 mg/d), cytotoxic or immunosuppressive drugs
• •Severe symptomatic heart (NYHA 3 or 4) or liver failure (Child Pugh B or C)
• •Respiratory failure requiring oxygenotherapy
• •Ongoing infection, autoimmune disease or cancer
• •Pregnant (e.g., positive human chorionic gonadotrophin \[HCG\] test) or lactating patients
• •Risk of pregnancy: any woman who does not fulfil one of the following criteria:
• •* post-menopausal (aged \> 45 years with amenorrhea for more than 2 years, or of any age with amenorrhea for more than 6 months and an FSH level \> 40 mUI / mL)
• •* permanent sterilisation (e.g., occlusion/bilateral ligature of the fallopian tubes, hysterectomy, bilateral salpingectomy, bilateral ovariectomy) or constitutional sterility
• •* of childbearing age and using an efficient method of contraception, begun at least 28 days before inclusion. Efficient contraception methods are: oral, injectable or implantable hormonal methods intra-uterine devices sterilisation of the male partner if he is the sole partner abstinence, if compatible with the preferred and usual lifestyle of the individual NB: if child bearing potential changes during the study, the woman must start taking one of the efficient methods of contraception as described above.
• •Patients with psychiatric or cognitive disorders rendering them unable to give written informed consent
• •Patients unwilling to participate in the study
• •Hypersensitivity to the active substances in Ketosteril®
• •Hypercalcaemia
• •Hypophosphatemia
• •Patient under a legal protection (curatorship or tutorship)