Diuretic Testing in Chronic Kidney Disease

Exclusion Criteria

• •Known intolerance or allergy to the diuretics
• •Current systemic chemotherapy for malignancy
• •Kidney transplant recipient
• •Use of calcineurin-inhibitors
• •Life expectancy \< 12 months
• •Current immunosuppressive treatment for glomerulonephritis
• •Incapacitated subjects or subjects who are deemed unfit to adequately adhere to instructions from the research team
• •Hypokalemia or hyperkalemia (K+ \< 3.0mmol/L or K+ \> 5.5 mmol/L) at inclusion visit
• •Hypo- or hypernatremia (Na+ \< 130 mmol/L or Na+ \> 150mmol/L) at inclusion visit
• •Inherited tubulopathy as the cause of CKD
• •Autosomal dominant polycystic or tubulointerstitial kidney disease causing CKD
• •Clinically relevant heart failure (New York Heart Association class III or IV)
• •Therapy-resistant hypertension, defined as systolic blood pressure \> 180mmHg at the inclusion visit
• •Current treatment with inhibitors of Organic anion transporters: probenecid, pravastatin, cimetidine, cephalosporins, acetazolamide \[22\]
• •Active hepatitis during last outpatient visit
• •Liver cirrhosis in advanced stage (Child-Pugh B or C)
• •Active drug- or alcohol abuse
• •Not being able to tolerate a 28-day washout of one of the drugs interfering with diuretic testing.
• •Women who are pregnant, breastfeeding, or planning on becoming pregnant before the test day