Add-on Diuretics in Acute Decompensated Heart Failure

Exclusion Criteria

• •1. Type 1 diabetes.
• •2. Chronic kidney disease with estimated glomerular filtration rate (eGFR) \<30 mL/min per 1.73 m² or end-stage kidney failure with the need for chronic dialysis treatment.
• •3. A systolic blood pressure of less than 90 mmHg.
• •4. Cardiogenic shock.
• •5. Receipt of acetazolamide maintenance therapy.
• •6. Receipt of an SGLT2 inhibitor, thiazide, or thiazide-like diuretic in the 48 hrs before randomization.
• •7. Any cause of heart failure leading to decompensation that will need urgent management (eg, acute coronary syndrome, unstable arrhythmias, acute pulmonary embolism).
• •8. Pregnant or breastfeeding women.
• •9. Moderate to severe anemia.