EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF

Exclusion Criteria

• •1. Acute heart failure caused by acute myocardial infarction.
• •2. Severe aortic valve stenosis.
• •3. Hemodynamic instability caused by poorly controlled arrhythmias.
• •4. Severe heart failure and high-degree atrioventricular block, and inadequate heart rate response to pacing during exercise.
• •5. Isolated pulmonary hypertension.
• •6. Poorly controlled symptomatic orthostatic hypotension.
• •7. Hypertrophic obstructive cardiomyopathy.
• •8. Stage 5 chronic kidney failure, defined as glomerular filtration rate \<15 ml/(min·1.73m²) or requiring dialysis.
• •9. Undergoing screening tests with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than or equal to 5 times the upper limit of the normal range defined by the center.
• •10. Awaiting a heart transplant or ventricular assist device implantation within six months, or having received a heart transplant.
• •11. A history of chronic lung disease except for COPD, previous lung surgery, or diseases affecting lung function, such as scoliosis.
• •12. Late-stage diseases other than heart failure.
• •13. Any medical history that could potentially affect protocol compliance, such as severe mental disorders, severe cognitive impairment, substance abuse, or addiction.
• •14. Severe language, psychological, or physical disabilities that prevent their participation in the program.
• •15. Pregnant or lactating women, or those of childbearing potential who are unwilling or unable to use effective contraceptive measures.
• •16. Involved in other interventional clinical trials.
• •17. Patients deemed unfit for participation in this study by the researchers.