Cao Aihua Qilu Hospital of Shandong University

CONTACT

Lead Sponsor

Qilu Hospital of Shandong University

Age

3 - 10 years

Sex

ALL

Healthy Volunteers

No

•1. ADOS-2 diagnostic criteria for autistic children
•2. Patients with NCOR related gene mutation detected by whole exon test;
•3. Age: 3-10 years old;
•4. The subject and (or) guardian sign the informed consent, agreeing that the researcher will cooperate with the clinical trial process and collect clinical data and peripheral blood and urine samples;

•1. have other pathogenic mutations (confidence higher than the NCOR related mutation);
•2. Boys over 10 years old;
•3. Allergic to spironolactone, used spironolactone one month before enrollment;
•4. Hyperkalemia, serum potassium concentration \> 5.5mmol/L;
•5. Renal insufficiency;
•6. Used related drugs one month before enrollment: potassium supplement, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, digoxin, coletenamine, acetylsalicylic acid, abiraterone;
•7. Fever (body temperature above 37.3°);
•8. Clinically significant metabolic, hematological, liver, immune, urological, endocrine, neurological, pulmonary, psychiatric, skin, allergic, renal, or other major conditions in the determination of ASD that may affect the interpretation of study findings or patient safety.