A Cohort Study on Increasing Blood Pressure Benefits in Sleep Apnea Patients After CPAP Treatment

Exclusion Criteria

• •1. Previously diagnosed with OSA and currently undergoing OSA treatment (such as CPAP, orthodontic devices, surgery, etc.);
• •2. Secondary hypertension caused by other reasons other than OSA, such as renal artery stenosis, kidney disease, Cushing's syndrome, primary aldosteronism;
• •3. Unstable condition (having experienced cardiovascular events or major surgeries in the past 3 months, severe sleepiness (ESS ≥ 16 points), or cognitive impairment that makes it impossible to cooperate, active mental illness or drug/alcohol abuse);
• •4. Rheumatic immune diseases and malignant tumors;
• •5. Large artery diseases (such as giant cell arteritis, arterial dissection, aneurysm, etc.);
• •6. Diseases that cannot accurately measure blood pressure (such as atrial fibrillation, upper limb vascular diseases);
• •7. Early-onset familial hypertension;
• •8. Any prescription or over-the-counter sleep aid (benzodiazepines, non-benzodiazepines, melatonin receptor agonists, trazodone, sedative antipsychotic/antidepressants containing sedative components, OTC containing sedative components) within 4 weeks before enrollment;
• •9. Allergic or contraindicated to the potential study drugs (trazodone, zopiclone);
• •10. Pregnant, lactating, or planning to become pregnant;
• •11. Frequent night shift work (≥ 3 nights/week) or circadian rhythm disorder (diagnosed by a doctor);
• •12. Participating in other interventional clinical trials.