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The Landscape of T1 Mapping for Disease Profiling in a Real-World Cohort
The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions. We aim to establish reference values for how heart tissue characteristics vary in various diseases, which will help doctors better interpret these advanced MRI measurements in clinical practice. The main questions it aims to answer are: What are the normal T1 mapping values for different heart diseases, and how do they compare to healthy hearts? Can we use the simpler "native T1" measurement (without contrast dye) instead of the more complex "ECV" measurement (which requires contrast dye) for diagnosis? Patients with various myocardial conditions will undergo CMR T1 mapping scans. We will analyze the MRI images and clinical records to establish disease-specific reference ranges for T1 mapping parameters, and validate the diagnostic accuracy of T1 mapping
Age
All ages
Sex
ALL
Healthy Volunteers
Yes
Fuwai Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Start Date
March 1, 2020
Primary Completion Date
October 1, 2026
Completion Date
December 1, 2026
Last Updated
January 21, 2026
2,000
ESTIMATED participants
Magnetic Resonance Imaging with Contrast
DIAGNOSTIC_TEST
Lead Sponsor
Chinese Academy of Medical Sciences, Fuwai Hospital
NCT07054073
NCT07444957
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT07436429