University Hospital Birmingham NHS Foundation Trust
Glenfield Hospital, Leicester
London Chest Hospital
Cytokinetics
Toronto General Hospital
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients in the original HCMR cohort with:
1. Obstructive HCM
* Males and females between 18 and 65 years of age
* BMI \< 35 kg/m2
* LVOT-G at entry as follows:
Resting gradient ≥50 mmHg OR Resting gradient ≥30 mmHg and \<50 mmHg with post-Valsalva LVOT-G ≥50 mmHg
• NYHA Class II or III or
2. Non-obstructive HCM
* Same criteria as above except resting LVOT-G is \<30mmHg and post-Valsalva gradient \<50mm Hg
* BMI \<40kg/m2
* Elevated NT-proBNP \> 300 pg/mL at the time of enrollment
* LVEF ≥55%
You may not be if
Paroxysmal atrial fibrillation or flutter documented prior to entry.
Paroxysmal or permanent atrial fibrillation requiring rhythm restoring treatment (eg, direct-current cardioversion, ablation procedure, or antiarrhythmic therapy) ≤6 months prior to entry. (This exclusion does not apply if atrial fibrillation has been treated with anticoagulation and adequately rate-controlled for \>6 months.)
History of syncope or sustained ventricular tachyarrhythmia with exercise within 6 months prior to entry.
Pregnancy due to potential risk of gadolinium to the fetus
Patients with a pacemaker that are pacer-dependent as they cannot undergo MRI
