Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty

Exclusion Criteria

• •lack of written consent to participate in the study or surgery
• •any private or professional relationship with the Investigators
• •genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others)
• •genetic metabolic diseases (e.g., gout and others)
• •genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others)
• •previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others)
• •patients undergoing revision after THA/TKA
• •autoimmune diseases in the patient's medical history
• •traumatic injury to the hip or knee joint
• •previous participation in the study.