Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea

Exclusion Criteria

• •Known non-OSA related conditions associated with sleep-disordered breathing (e.g., a central disorder of hypersomnolence, neurological, neuromuscular, or pulmonary disorder)
• •Use of sleep-inducing medications (e.g., other non-benzodiazepine sedative hypnotic-drugs \[e.g., zoldpidem\], benzodiazepines, non-selective antihistamines, trazodone, opiates, barbituates)
• •Known hypersensitivity reaction to eszopiclone
• •Contraindications to its use based on medical history or function (e.g., dizziness at baseline or established mobility problems or imbalance)
• •History of complex sleep behaviors (e.g., NREM or REM parasomnias)
• •Concomitant use of ≥ 2 servings of alcohol per night or other CNS depressant for 2 weeks prior or throughout the study
• •Sleep opportunity of less than 7 hours
• •Severe active depression or other mental health disorders (e.g., schizophrenia, bipolar disorder, personality disorder).
• •History of sleep-walking, sleep-driving, and engaging in other activities while not fully awake
• •Severe hepatic impairment (liver function tests 2 X the upper limit of normal)
• •Unstable medical condition (e.g., decompensated heart failure, end-stage chronic obstructive pulmonary disease, end-stage renal disease)
• •Females of childbearing potential who are pregnant, breastfeeding, or intend to become pregnant.