A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy

Exclusion Criteria

• •1. History of endocrine disorders which have significant impact on body weight;
• •2. Diagnosis of diabetes (except gestational diabetes), ketoacidosis or hypertonic state/coma;
• •3. HbA1c ≥6.5% at screening;
• •4. Fasting blood glucose ≥7.0 mmol/L or 2-hour blood glucose ≥11.1 mmol/L after oral glucose tolerance test (OGTT) at screening; participants with FBG ≥6.1 mmol/L but \<7.0 mmol/L require OGTT;
• •5. Have diagnosis of Cheyne Stokes Respiration, or diagnosis of Central or Mixed Sleep Apnea with % of mixed or central apneas/hypopneas ≥50%;
• •6. Respiratory and neuromuscular diseases that could interfere with the results of the trial;
• •7. Diagnosis of Obesity Hypoventilation Syndrome or daytime hypercapnia;
• •8. Change of body weight \>5% within 3 months prior to screening (self-reported);
• •9. Have a prior or planned surgical treatment for obesity (except liposuction or abdominoplasty if performed more than 1 year prior to screening);
• •10. Have received any medication for body weight loss and blood glucose lowering or medication that could lead to significant body weight increase, within 3 months prior to screening.