Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.

Exclusion Criteria

• •1. Consumption of foods or medications containing high levels of NAD+, NR, NAM, NMN, or niacin-related components (including Vitamin B3 and natural health products) within 3 months prior to screening；
• •2. History of major cardiovascular or cerebrovascular events, including myocardial infarction, angina, stroke, or hospitalization for arterial revascularization；
• •3. Systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg；
• •4. Diagnosis of malignant tumor；
• •5. Known allergy or history of severe adverse reactions to Coenzyme I injection or any of its components；
• •6. History of severe allergies or infusion reactions；
• •7. Women who are pregnant, breastfeeding, or planning pregnancy；
• •8. Severe hepatic or renal dysfunction: ALT or AST \> 5 times the upper limit of normal; glomerular filtration rate ≤ 30 mL/min/1.73 m²；
• •9. Concurrent participation in another clinical trial without completion of the follow-up period；
• •10. Other conditions deemed by the investigator as unsuitable for inclusion, such as psychiatric or psychological disorders.