Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

Association Between Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium According to Frailty Status in Older Surgical Patients: A Prospective Cohort Study

NCT07322744•Chinese PLA General Hospital

View on ClinicalTrials.gov

Summary

Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.

Eligibility

Age

65 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Aged ≥65 years;
•Underwent elective noncardiac, nonneurosurgical procedures;
•Completed the preoperative health and functional status questionnaire.

Exclusion Criteria

•Severe dementia, language disorders, significant hearing or visual impairments, or coma;
•Cognitive function below the Mini-Mental State Examination thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher);
•Surgery performed under local anesthesia or monitored anesthesia care;
•Missing lymphocyte or monocyte count data;
•Missing postoperative delirium assessment;
•Incomplete preoperative FRAIL scale evaluation;
•Missing data for more than 20% of covariates.

Locations (1)

28 Fuxing Road, Haidian District

Beijing, China

Key Dates

Start Date

April 1, 2020

Primary Completion Date

April 30, 2022

Completion Date

December 30, 2023

Last Updated

January 9, 2026

Enrollment

6,475

ACTUAL participants

Conditions

Postoperative Delirium (POD)Frailty at Older AdultsLymphocyte

INS, B Cells and Microbiota

NCT04924712

MicrobiotaB-lymphocytes+2 more

View study

RECRUITING

National Longitudinal Cohort of Hematological Diseases

NCT04645199

Multiple MyelomaAcute Myeloid Leukemia+15 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 9, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

Inclusion Criteria

Exclusion Criteria

INS, B Cells and Microbiota

National Longitudinal Cohort of Hematological Diseases

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