Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty

Exclusion Criteria

• •Chronic renal disease at stage G3b or higher or glomerular filtration rate \<30 ml/min/1.73m2.
• •Hepatic insufficiency, cirrhosis.
• •Neuromuscular and neurodegenerative diseases (amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myasthenia gravis, Parkinson's disease, etc.).
• •Severe or very severe chronic obstructive pulmonary disease (COPD) (GOLD III-IV).
• •Moderate or severe chronic heart failure (NYHA 3-4).
• •Central sensitivity syndrome (fibromyalgia and chronic fatigue syndrome).
• •Moderate or severe cognitive impairment (GDS≥4).
• •Moderate-severe dependence for basic activities of daily living (preintervention Barthel index \<60 points).
• •Hemiparesis, amputation or malformation of any limb.
• •Consumption of creatine monohydrate supplements in the last 6 months.