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Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals | Clinical Trials | Clareo Health

RECRUITINGNA

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial

NCT07287306•Wecare Probiotics Co., Ltd.

View on ClinicalTrials.gov

Summary

Gut microbiota play a key role in polyphenol metabolism, participating in the breakdown of dietary components and producing various small molecule metabolites that affect human health. However, little is currently known about how gut microbes metabolize dietary compounds and produce bioactive metabolites. This study aims to use metabolomics to precisely identify food-derived metabolites in the blood to investigate whether probiotics (BLa80, LRa05) can enhance the breakdown of dietary components and improve their absorption and utilization in the human body.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Male or female participants aged 18 to 60 years;
•2. Healthy individuals;
•3. Participants must provide written informed consent.

Exclusion Criteria

•1. History of gastrointestinal surgery, other gastrointestinal diseases, metabolic disorders, immunodeficiency, hyperthyroidism, or cardiac or liver disease;
•2. Use of immunosuppressants;
•3. Pregnant or breastfeeding women;
•4. Participants who have taken antibiotics or probiotics within the previous 3 months;
•5. Planned surgery during the study period;
•6. Patients with neurological disorders or psychiatric illness.

Locations (1)

The First Affiliated Hospttal, Sun Yat-sen University

Guangzhou, Guangdong, China

Key Dates

Start Date

December 10, 2025

Primary Completion Date

June 20, 2026

Completion Date

November 15, 2026

Last Updated

December 17, 2025

Enrollment

375

ESTIMATED participants

Conditions

Healthy Individuals

Interventions

Placebo

DIETARY_SUPPLEMENT

BLa80

DIETARY_SUPPLEMENT

LRa05

DIETARY_SUPPLEMENT

Effect of Heel Lift Insole on Kinematics and Kinetics of the Lower Limb and Lumbar Spine Among Healthy Individuals

NCT07047300

Healthy Individuals

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RECRUITING

Exercise Capacity, Muscle Oxygenation, and Physical Activity Between Patients With Interstitial Lung Disease

NCT06948942

Interstitial Lung Diseases (ILD)Healthy Individuals+3 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 17, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals

Inclusion Criteria

Exclusion Criteria

Effect of Heel Lift Insole on Kinematics and Kinetics of the Lower Limb and Lumbar Spine Among Healthy Individuals

Exercise Capacity, Muscle Oxygenation, and Physical Activity Between Patients With Interstitial Lung Disease

PULP SENSIBILITY AND MASSETER INHIBITORY REFLEX IN DIABETIC POLYNEUROPATHY

Effects of Thumb Manipulation on Hand Grip Strength, Function, and Sensation

INVESTIGATION OF PERIPHERAL OXYGEN SATURATION VALUES MEASURED IN DIFFERENT BODY POSITIONS AND FINGERS IN HEALTHY YOUNG ADULT INDIVIDUALS

Normal Variation of T1 Values With Cardiac Magnetic Resonance in Healthy Individuals