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Pollution Intervention to Impact Kids Asthma Study | Clinical Trials | Clareo Health

RECRUITINGNA

Pollution Intervention to Impact Kids Asthma Study

NCT07261423•University of Pittsburgh

Summary

The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children. It will also learn about children with asthma who report being more sensitive to outdoor air pollution. The main questions it aims to answer are: * Does adding either information about the EPA-AQI or commercial AQI improve asthma outcomes over time? * Are there changes in nasal gene expression in children with asthma who report they are more sensitive to outdoor air pollution? Researchers will compare EPA-AQI and the commercial-AQI groups to a control group to either AQI works to improve asthma. Participants will: * Receive standardized outdoor air pollution education and an asthma action plan * Provide nose and blood specimens * Have visits every 4 weeks for 48 weeks, 10 will be conducted by telephone calls and 3 visits will be in person.

Eligibility

Age

8 - 17 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•A healthcare provider diagnosis of persistent asthma (Steps 2-5 as defined by US guidelines) or intermittent asthma (Step 1) + at least one severe asthma exacerbation (defined by American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria as requiring at least 3 days of systemic steroids or an Emergency Department/Urgent Care visit requiring systemic steroids) in the prior 12 months
•Home access to a smartphone or internet
•Primary residence in Allegheny County, PA
•One participant per household
•Age 8 -17 years
•Healthcare provider evaluation for asthma in the prior year

Exclusion Criteria

•Diagnosis of other active chronic respiratory diseases (e.g., cystic fibrosis, bronchopulmonary dysplasia, etc.)
•Neuromuscular disorder
•Chronic disorder limiting independent ambulation (e.g., spastic quadriplegia, etc.)
•Cyanotic heart disease
•Plans to relocate from Allegheny County, PA in the next year (12 months)
•Use of intranasal or oral/intramuscular/intravenous corticosteroids 4 weeks prior to randomization
•Current participation in another asthma intervention trial

Locations (1)

UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Key Dates

Start Date

February 24, 2026

Primary Completion Date

January 1, 2030

Completion Date

January 1, 2030

Last Updated

February 27, 2026

Enrollment

351

ESTIMATED participants

Conditions

Childhood AsthmaAsthma ControlAsthma ExacerbationAir Pollution, Risk Reduction Behaviors

Interventions

EPA-AQI

BEHAVIORAL

Commerical-AQI

BEHAVIORAL

Education and plan

BEHAVIORAL

Contacts

Pediatric Asthma Center

CONTACT

877-296-9026 franziska.rosser2@chp.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 27, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Pollution Intervention to Impact Kids Asthma Study

Inclusion Criteria

Exclusion Criteria

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