Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department

Exclusion Criteria

• •Acute exacerbation of asthma during the last 30 days
• •Clinical suspicion of acute exacerbation of asthma due to anaphylaxis, pneumothorax, pneumomediastinum, pneumonia or atelectasis.
• •At least ONE of the following serious signs: drowsiness, confusion, auscultatory silence
• •Clinical suspicion of another pathology that could explain the respiratory failure such as heart failure, laryngeal obstruction, pulmonary embolism, etc
• •Patients with neurological (Glasgow \< 13) or hemodynamical failure (Mean Arterial Pressure \< 65 mmHg)
• •contraindication to treatment with a beta-2-adrenergic agonist
• •History of hypersensitivity (allergy) to terbutaline or any of the constituents
• •Contraindication to OHD
• •Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, people assessed GIR1 or GIR 2 (AGGIR grid), adults under legal protection
• •Pregnant or breastfeeding women, Women at age to procreate and not using effective contraception