Umbilical Cord Mesenchymal Stem Cell Secretome Administration in Severe Erectile Dysfunction Non-responsive to Sildenafil

Exclusion Criteria

• •Anatomical abnormalities of the penis that are clinically visible, such as Peyronie's disease, a history of priapism, a history of penile implants, skin irritation, and lesions in the area surrounding the penile skin.
• •Active and significant systemic or local infection.
• •History of bleeding or blood clotting disorder therapy.
• •History of systemic autoimmune disorders and immunosuppressive treatment
• •History of prostate surgery, history of malignancy, or a PSA level \> 4 ng/mL.
• •Untreated hypogonadism or low serum total testosterone (\<200 ng/dL).
• •Uncontrolled hypertension or hypotension (systolic blood pressure \>170 or \<90 mmHg, and diastolic blood pressure \>100 or \<50 mmHg).
• •Unstable cardiovascular disease (e.g., unstable angina, myocardial infarction within the last 6 months, and congestive heart failure).