DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes

Exclusion Criteria

• •1. Coexisting dementia or severe cognitive impairment (MoCA \< 17).
• •2. Coexisting severe depression, defined as a Hamilton Depression Rating Scale (HAMD) score ≥ 20.
• •3. Prior use of cognitive-enhancing drugs, such as donepezil or memantine.
• •4. Allergy to DPP4 inhibitors.
• •5. Past or current use of DPP4 inhibitors.
• •6. Past or current use of GLP-1 agonists.
• •7. Type 1 diabetes, latent autoimmune diabetes in adults, secondary diabetes, malignant tumors, autoimmune diseases, or other endocrine-related diseases.
• •8. Moderate or severe liver or kidney dysfunction.
• •9. Chronic or acute pancreatitis.
• •10. Pregnancy or lactation.
• •11. Severe infection or severely impaired immune response.
• •12. Participation in other clinical trials.
• •13. Past or current use of insulin therapy.