Brain-Oscillation-Synchronized Stimulation to Enhance Motor Recovery in Early Subacute Stroke

Exclusion Criteria

• •Subjects presenting with any of the following criteria will not be included in the trial:
• •1. Hemorrhagic stroke (this refers to primary intracerebral hemorrhage only; hemorrhagic transformation of ischemic infarcts is not an exclusion criterion)
• •2. Estimated life expectancy \< 12 months
• •3. Presence of intracranial ferromagnetic metal (extracranial stents ≥10 cm away from the TMS coil are acceptable) in accordance with current safety guidelines \[18\]
• •4. Intraocular metal, cochlear implants
• •5. If TMS might interact with sensors of active implants (e.g., intra-cardiac defibrillators).
• •6. If a cranial bone gap affects currents induced by TMS (such as after craniotomy).
• •7. History of seizures or epilepsy.
• •8. Treatment intervention can't be started within 14 days after onset of stroke.
• •9. Women during pregnancy and lactation.
• •10. Participation in other studies if they are MDR or AMG studies or there is otherwise a high risk of insurance law issues intervening between two studies. In case of uncertainty, competing insurances must be contacted prior to participation
• •11. persistent addiction disorder (except for nicotine dependence)
• •12. CNS malignoma
• •13. If there is any concern by the investigator regarding the safe participation of the subject in the study or for any other reason the investigator considers the subject inappropriate for participation in the study.
• •14. The ability to consent for patients who are unable to speak will be assessed on the basis of the NIHS-Score by an independent physician (details see chapter 21 and appendix).